Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization

Chun Chen, John J. Tyson, William Baumann

doi: http://dx.doi.org/10.1101/031245

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Abstract

We present a mathematical model that captures the transitions among three experimentally observed estrogen sensitivity phenotypes in breast cancer cells. Based on this model, a population-level model is created and used to explore the optimization of a therapeutic protocol

http://biorxiv.org/content/early/2015/11/10/031245