Sunday, November 22, 2015

Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization

Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization

Abstract

We present a mathematical model that captures the transitions among three experimentally observed estrogen sensitivity phenotypes in breast cancer cells. Based on this model, a population-level model is created and used to explore the optimization of a therapeutic protocol

http://biorxiv.org/content/early/2015/11/10/031245