Physics-based multiscale mass transport model in drug delivery and tumor microenvironment

Arturas Ziemys, Milos Kojic, Mauro Ferrari

doi: http://dx.doi.org/10.1101/031252

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Abstract

We describe multiscale transport model, which was developed to simulate drug diffusion and convection in tissues and drug vectors. Models rely on material properties and physical laws of transport. Our methods show that drug transport analysis may provide deep insight into mechanisms of pharmacokinetics useful in nanotherapeutics and transport study within tumor microenvironment. Because the method relies on material properties and structures, the approach can help studying phenotypical differences as well.

http://biorxiv.org/content/early/2015/11/10/031252