Saturday, January 30, 2016

Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes


Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes

Mark Robertson-Tessi, Robert J Gillies, Robert A Gatenby, Alexander RA Anderson

Abstract
A hybrid multiscale mathematical model of tumor growth is used to investigate how tumoral and microenvironmental heterogeneity affect treatment outcomes. A key component of this model is normal and tumor metabolism and its interaction with microenvironmental factors. In early stages of growth, tumors are stratified, with the most aggressive cells developing within the interior of the tumor. Simulations suggest that in some cases chemotherapy may increase the metabolic aggressiveness of a tumor due to drug-mediated selection.