The role of contact inhibition in intratumoral heterogeneity: An off-lattice individual based model
Abstract
We
present a model that shows how intratumoral heterogeneity, in terms of
tumor cell phenotypic traits, can evolve in a tumor mass as a result of
selection when space is a limited resource. This model specifically
looks at the traits of proliferation rate and migration speed. The
competition for space amongst individuals in the tumor mass creates a
selection pressure for the cells with the fittest traits. To allow for
organic movement and capture the invasive behavior, we use an
off-lattice individual-based model.
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